{"id":676,"date":"2022-02-16T06:54:29","date_gmt":"2022-02-16T06:54:29","guid":{"rendered":"https:\/\/cilantro.ro\/blog\/?p=676"},"modified":"2025-10-01T07:28:24","modified_gmt":"2025-10-01T07:28:24","slug":"care-e-rolul-probioticelor-in-galaxia-microbiomului","status":"publish","type":"post","link":"https:\/\/cilantro.ro\/blog\/index.php\/2022\/02\/16\/care-e-rolul-probioticelor-in-galaxia-microbiomului\/","title":{"rendered":"Care e rolul probioticelor \u00een &#8222;galaxia&#8221; microbiomului?"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Printre lucrurile bune pe care le-a adus pandemia se num\u0103r\u0103 si awareness-ul legat de microbiom \u00een general si rolul lui extrem de important \u00een performan\u0163a sistemului imunitar, \u00een particular.   <\/p>\n\n\n\n<!--more-->\n\n\n\n<p class=\"wp-block-paragraph\">Ca s\u0103 putem ajunge la discu\u0163ia legat\u0103 de probiotice, e de folos s\u0103 vorbim mai \u00eent\u00e2i despre microbiom, definit ca fiind num\u0103rul total al bacteriilor bune si rele din intestin. Mai exact, 100 trilioane de celule cu greutatea aproximativ\u0103 de 2,3 kg,  pentru care organismul nostru func\u0163ioneaz\u0103 ca si gazd\u0103. Un num\u0103r impresionant fa\u0163\u0103 de cele 37,2 trilioane de celule umane, ceea ce ne-ar face s\u0103 fim mai mult bacterii dec\u00e2t oameni, cum glumea unul dintre profesorii mei de la scoala de nutri\u0163ie din New York, cardiologul Mehmet Oz, mai cunoscut ca si Dr Oz. Ce ar mai fi de ad\u0103ugat despre microbiom ar fi rolul acestuia \u00een r\u0103spunsul imunitar (70%), lupta \u00eempotriva inflama\u0163iei cronice, a infec\u0163iilor cu microorganisme periculoase si \u00een s\u0103n\u0103tatea creierului, respectiv \u00een stabilirea conexiunii creier-intestin.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Etimologia probioticelor vine din latinescul &#8222;pro&#8221; si grecescul &#8221; biotic&#8221;, care \u00eenseamn\u0103 &#8222;pentru via\u0163\u0103&#8221;. Denumirea reuneste sute de tipuri de bacterii (i.e.:bune) clasificate ca si probiotice, cele mai cunoscute si mai folosite fiind speciile Lactobacilllus si Bifidobacterium. Te invit s\u0103 descoperi mai jos rolurile importante ale celor 2 specii \u00een men\u0163inerea san\u0103t\u0103\u0163ii microbiomului:<\/p>\n\n\n\n<ol class=\"wp-block-list\"><li><strong>Lactobaccilus<\/strong> <strong>sp<\/strong>&#8211; produce lactaza necesara digestiei lactozei din lapte diger\u00e2nd \u00een acelasi timp si al\u0163i carbohidra\u0163i care au ca produs de reac\u0163ie acidul lactic. Acesta,  prin crearea mediului acid, lupt\u0103 \u00eempotriva microorganismelor patogene si faciliteaz\u0103 absorb\u0163ia unora dintre micronutrien\u0163i: Ca, Cu, Mg si Fe, vit D si K. Cele mai cunoscute specii sunt:<ul><li><em>L. acidophillus<\/em> &#8211; care men\u0163ine integritatea peretelui intestinal, faciliteaz\u0103 digestia si optimizeaz\u0103 func\u0163ia imun\u0103. Se g\u0103seste \u00een iaurt, kefir si m\u00e2nc\u0103ruri fermentate.<\/li><li><em>L. fermentum<\/em> &#8211; produce antioxidan\u0163i ce neutralizeaz\u0103 toxinele ( i.e. produse de Schigella si Clostridium). Se g\u0103seste \u00een mur\u0103turi, kimchi, miso, tempeh, etc.<\/li><li><em>L. brevis si L. bulgaricus <\/em>&#8211; produc acid lactic si se g\u0103sesc \u00een mur\u0103turi si c\u00e2teva specii de iaurt.<\/li><li><em>L. plantarum<\/em> &#8211; produce antibioticul natural lactolin\u0103 si aminoacidul L-lizin\u0103, cu rol antiviral.<\/li><li><em>L. rhamnosum<\/em> &#8211; ajut\u0103 la digestia lactozei, produce acid lactic si protejeaz\u0103 peretele intestinal. Se g\u0103seste \u00een br\u00e2nzeturi, kefir si varz\u0103 murat\u0103.<\/li><li><em>L. reuteri  <\/em>&#8211; se g\u0103seste at\u00e2t \u00een intestin c\u00e2t si \u00een cavitatea oral\u0103. Are rol \u00een sc\u0103derea concentra\u0163iei bacteriilor care determin\u0103 apari\u0163ia cariilor si lupt\u0103 \u00eempotriva inflama\u0163iei cronice. Surse importante sunt kefirul si iaurtul.<\/li><\/ul><\/li><li><strong>Bifidobacterium sp<\/strong>. rezid\u0103 \u00een mucoasa intestinului gros si \u00een tractul vaginal, lupt\u00e2nd \u00eempotriva bacteriilor patogene si a fungilor,  asigur\u00e2nd controlul ph-ului si absorb\u0163ia unora dintre nutrien\u0163i cum ar fi: Fe, Ca, Mg si Zn. Cele mai importante specii sunt:<ul><li><em>B. animalis<\/em> &#8211; faciliteaz\u0103 digestia si \u00eent\u0103rirea sistemului imunitar. Se g\u0103seste \u00een br\u00e2nzeturi intens probiotice cum ar fi: Swiss, provolone, cheddar, Gouda, etc.<\/li><li><em>B breve<\/em> &#8211; ajut\u0103 la absorb\u0163ia nutrien\u0163ilor si \u00een plus, scindeaz\u0103 fibrele vegetale pentru a putea fi absorbite. Principalele surse din aportul alimentar sunt iaurtul si varza murat\u0103.<\/li><li><em>B. ifantis<\/em> &#8211; stimuleaz\u0103 producerea de citokine. E folosit pentru suplimentarea formulelor pentru sugari si se gaseste \u00een iaurt, kefir si br\u00e2nz\u0103.<\/li><li> <em>B. longum<\/em> &#8211; lupt\u0103 \u00eempotriva bacteriilor si a fungilor, protej\u00e2nd \u00eempotriva diareei si a st\u0103rii de grea\u0163\u0103 provocata de antibiotice . \u00ce\u0163i po\u0163i asigura un nivel optim din aceast\u0103 specie prin includerea iaurtului \u00een planul t\u0103u alimentar.<\/li><\/ul><\/li><\/ol>\n\n\n\n<p class=\"wp-block-paragraph\">Care sunt afec\u0163iunile\/dezechilibrele \u00een care suplimentarea cu probiotice este recomandat\u0103?<\/p>\n\n\n\n<ol class=\"wp-block-list\"><li><strong>Alergii de sezon<\/strong> &#8211; un studiu publicat \u00een 2017, desf\u0103surat pe parcursul a 8 s\u0103pt\u0103m\u00e2ni pe 173 de adul\u0163i  a ar\u0103tat diminuarea simptomelor de alergie ( rinoree, nas \u00eenfundat, etc) \u00een cazul grupului c\u0103ruia i s-a adminstrat probiotic ( L+B) fa\u0163\u0103 de grupul de control.<\/li><li><strong>Artrit\u0103<\/strong> &#8211; un studiu din 2014 care a inclus  timp de 8 saptam\u00e2ni 46 de adul\u0163i cu artrit\u0103 reumatoid\u0103, a eviden\u0163iat sc\u0103derea nivelului de markeri inflmatori, la grupului c\u0103ruia i s-a administrat probiotic.<\/li><li><strong>Hipertensiune arterial\u0103<\/strong> &#8211; o meta analiz\u0103 care a luat \u00een calcul 9 studii ce au reunit 543 de pacien\u0163i, a urm\u0103rit corela\u0163ia dintre administrarea de probiotic si nivelul tensiunii arteriale, pentru adul\u0163ii care \u00eenregistrau anterior valori mai mari de 130\/85. Rezultatul a demonstrat c\u0103 aportul de probiotic a antrenat sc\u0103derea tensiunii sistolice cu 3,56 mmHg si a tensiunii diastolice cu 2.38 mm Hg.<\/li><li><strong>Cancer <\/strong>&#8211; un studiu publicat \u00een 2016 de catre PLOS ONE care a vut ca subiec\u0163i soarecii de laborator, a ar\u0103tat ca administrarea de L. johnsonii  a sc\u0103zut cu 50% inciden\u0163a leucemiei, limfomului si a altor tipuri de cancer.<\/li><li><strong>Depresie si anxietate<\/strong> &#8211; un studiu efectuat \u00een 2017 tot pe soarecii de laborator a ar\u0103tat c\u0103 administrarea Lactobacillus sp. a determinat sc\u0103derea nivelului plasmatic de kinurenin\u0103, un aminoacid implicat in mecanismul depresiei.<\/li><li><strong>Probleme gastrointestinale<\/strong>. \u00cen cazul patologiilor intestinale s-au f\u0103cut cele mai multe studii, care au ar\u0103tat rezultate \u00eencurajatoare \u00een diareea determinat\u0103 de administrarea de antibiotice, \u00een boala Crohn, colita ulcerativ\u0103, sindrom de colon iritabil, etc.<\/li><li><strong>Patologii cardiovasculare<\/strong> &#8211; un studiu publicat \u00een 2016 \u00een Journal of Applied Microbiology, a indicat c\u0103 probioticul Akkermania muciniphilla (ce se g\u0103seste \u00een struguri, merisoare si rodii) a sc\u0103zut marcat nivelul de inflama\u0163ie ce contribuie la agregarea pl\u0103cii arteriale.<\/li><li><strong>Suprapondere <\/strong>&#8211; o meta analiz\u0103 publicat\u0103 \u00een 2016 ce a inclus 2.000 de adul\u0163i s\u0103n\u0103tosi supraponderali, a ar\u0103tat c\u0103 dup\u0103 administrarea probioticelor timp de 8 s\u0103pt\u0103m\u00e2ni a scazut IMC (Indexul de masa corporala). Mecanismul de ac\u0163iune al probioticului \u00een acest caz a fost diminuarea absorb\u0163iei grasimilor din aportul alimentar si &#8222;desc\u0103rcarea&#8221; GLP-1, hormon cu rol \u00een reducerea apetitului.<\/li><\/ol>\n\n\n\n<p class=\"wp-block-paragraph\">Acum c\u0103 am trecut \u00een revist\u0103 beneficiile extraordinare ale probioticelor si pentru c\u0103 am men\u0163ionat deja care ar fi sursele alimentare, te intrebi probabil cum s\u0103 faci suplimentarea \u00eentr-un mod eficient si s\u0103n\u0103tos.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Ei, aici este \u00eenc\u0103 un battlefield, pentru c\u0103 pia\u0163a global\u0103, evaluat\u0103 la 3.7 miliarde $ in 2016 si estimat\u0103 a atinge nivelul de 17,4 miliarde $ \u00een 2027, e inundat\u0103 de produse cu statutul de supliment nutritiv, care se bucur\u0103 de &#8222;privilegiul&#8221; de a nu fi reglementate\/testate de FDA sau agentiile nationale\/europeana de medicamente. Asta \u00eenseamn\u0103 c\u0103 \u00een cazul cel mai bun, unele dintre ele sunt inerte, deci total nefolositoare. \u00cen cazul cel mai r\u0103u, dupa cum se va vedea mai jos, probioticul poate con\u0163ine substan\u0163e care s\u0103 agraveze patologii preexistente (boal\u0103 celiac\u0103, etc).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u00cen final, ca s\u0103 facem un pic de lumin\u0103 \u00een h\u0103\u0163isul informa\u0163iilor, iat\u0103 la ce ar fi interesant sa fii atent(\u0103) c\u00e2nd vrei s\u0103 cumperi un probiotic:<\/p>\n\n\n\n<ol class=\"wp-block-list\"><li><em>Tipurile de specii. <\/em>Sunt producatori care cultiv\u0103 anumite specii doar pentru c\u0103 sunt mai ieftine, deci produsul respectiv ar putea s\u0103  nu raspund\u0103 nevoilor tale de s\u0103n\u0103tate .<\/li><li><em>Cantitatea<\/em>. \u00cen general, prospectele probioticelor listeaz\u0103 concentra\u0163ii \u00eentre 1-100 miliarde CFU (colony forming units). Cele \u00eentre 1-10 miliarde CFU sunt marketate ca fiind recomandate generalist pentru &#8222;san\u0103tatea aparatului digestiv si a sistemului imunitar&#8221;. Cele cu 15-45 miliarde CFU targeteaz\u0103 probleme de s\u0103n\u0103tate specifice. Aici i\u0163i recomand s\u0103 urmaresti brandurile care de obicei au si studii clinice si pot dovedi \u00een acest fel c\u0103, concentra\u0163ia men\u0163ionat\u0103 pe etichet\u0103 se regaseste \u00eentr-adevar si \u00een produs. <\/li><li><em>Calitatea.<\/em> Un studiu publicat \u00een 2015 de Columbia Medical Center a ar\u0103tat c\u0103 12 din 22 cele mai v\u00e2ndute probiotice din Statele Unite con\u0163ineau urme de gluten (desi eticheta spunea c\u0103 nu con\u0163in, <em>deci pot fi administrate si celor cu boala celiaca<\/em>).<\/li><\/ol>\n\n\n\n<p class=\"wp-block-paragraph\">Viitorul ne va aduce rezultate foarte interesante ale cercetarii, pentru c\u0103 studiul microbiomului este \u00eenc\u0103 la \u00eenceput. P\u00e2na atunci, ar fi indicat ca probioticele sa fie o prezen\u0163\u0103 permanent\u0103 \u00een modelul t\u0103u alimentar  si dac\u0103 medicul t\u0103u curant si\/sau farmacistul \u00ee\u0163i recomand\u0103 suplimentarea cu probiotic, acum stii deja ce \u00eentreb\u0103ri s\u0103 pui ca s\u0103 te asiguri c\u0103 ai parte de produsul potrivit \u0163ie.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u00cenchei cu un citat (care e \u00een acelasi timp si un \u00eendemn \ud83d\ude42 ) din Deepak Chopra, un alt profesor de-al meu : <em><strong>&#8222;Eat a plant based diet which act like prebiotic and probiotics in the gut!&#8221;.<\/strong><\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">R\u0103m\u00e2neti curiosi, s\u0103n\u0103tosi si optimisti!<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">P.S.: Ca s\u0103 mai adaug o nota pozitiv\u0103, ca de obicei, pot s\u0103-\u0163i spun c\u0103 dup\u0103 un studiu atent al pie\u0163ei si dup\u0103 ce am \u00eencercat multe brand-uri de probiotice, am g\u0103sit unul potrivit, rezultat al cercet\u0103rii unor specialisti dintr-o universitate european\u0103. Deci se poate \ud83d\ude42 . La pre\u0163ul corect, bine\u00eenteles.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Surse:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.longdom.org\/scholarly\/probiotics-journals-articles-ppts-list-2774.html\">Probiotics | List of High Impact Articles | PPts | Journals | Videos (longdom.org)<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.nature.com\/articles\/nrgastro.2014.66\">The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic | Nature Reviews Gastroenterology &amp; Hepatology<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Harvard Medical School Guide -The benefits of probiotics<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Printre lucrurile bune pe care le-a adus pandemia se num\u0103r\u0103 si awareness-ul legat de microbiom \u00een general si rolul lui extrem de important \u00een performan\u0163a sistemului imunitar, \u00een particular.<\/p>\n","protected":false},"author":2,"featured_media":745,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7,14,3,4,12],"tags":[26,43,24],"class_list":["post-676","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-imunitate","category-longevitate-si-wellbeing","category-nutritie","category-nutritie-si-imunitate","category-sanatate-si-echilibru","tag-imunitate","tag-probiotice-pentru-sanatate","tag-stil-de-viata-sanatos","entry"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.10 - 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